If the valve stem to guide clearance is excessive then a new set of valve stem oil seals won't be able to seal sufficiently. An excessive guide clearance will allow the valve to move out of position slightly as it is opened and in doing so the stem seal will deform, instead of the seal scraping the oil off the valve stem as the valve opens it allows some of the oil to remain on the stem, this oil is then scraped off by the stem seal as the valve closes, the oil then runs down to the valve head and then either into the combustion chamber (if it's an inlet valve) or out of the exhaust (if it's an exhaust valve).
Replacing the valve guides is not something I would say is very common, however from experience the previous two 4E cylinder heads I've rebuilt have required new exhaust valve guides.