I run 16x8's on a 215 tyre on the front with 15"s on a 195 tyre on the back. Obviously im in a totally different circumstance to most, but mine needs to handle! Which it does. Also do not struggle with traction issues.
With reference to Pauls post a few things to bare in mind.
Match your rolling radius if you go bigger wheels/tyres and your speedo/gearing should not be to badly effected.
Weight wise, my front wheels weight are light, and weigh not that much different to my backs.
Worse of the start line? well you get more traction on a bigger/wider rim.
Bigger wheels on the back? More grip on the back, more your going to encourage understeer. Lovely.
Additionally, you mention 45 and 50 profiles, are you assuming the same width of tyre, Bare in mind a 195/45 will have a different height sidewall to a 205/45 side wall as the 45 is the percentage of the width.